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Immunotherapeutic targeting of surfaceome heterogeneity in AML
Immunotherapy remains underexploited in acute myeloid leukemia (AML) compared to other hematological malignancies. Currently, …
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Transposable elements regulate thymus development and function
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by …
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BamQuery - a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens
MHC-I-associated peptides deriving from non-coding genomic regions and mutations can generate tumor-specific antigens, including …
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BamQuery - a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens
Toward computing attributions for dimensionality reduction techniques
Summary - We describe the problem of computing local feature attributions for dimensionality reduction methods. We use one such method …
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Toward computing attributions for dimensionality reduction techniques
Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers
Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces durable anti-tumor immune responses via T …
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Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia
Early T-cell development is precisely controlled by E proteins, that indistinguishably include HEB/TCF12 and E2A/TCF3 transcription …
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Proteogenomics and Differential Ion Mobility Enable the Exploration of the Mutational Landscape in Colon Cancer Cells
The sensitivity and depth of proteomic analyses are limited by isobaric ions and interferences that preclude the identification of low …
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The tumor-specific antigen landscape of acute myeloid leukemia
In theory, tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but none have been identified in acute …
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Two types of human TCR differentially regulate reactivity to self and non-self antigens
Based on analyses of TCR sequences from over 1,000 individuals, we report that the TCR repertoire is composed of two ontogenically and …
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Two types of human TCR differentially regulate reactivity to self and non-self antigens
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
Cholesterol homeostasis has been proposed as one mechanism contributing to chemoresistance in AML and hence, inclusion of statins in …
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