Laboratoire Lemieux
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Azadeh Hajmirza
,
Laura Simon
,
Jalila Chagraoui
,
Nadine Mayotte
,
Jean-Francois Spinella
,
Tara Macrae
,
Bernhard Lehnertz
,
Thierry Bertomeu
,
Jasmin Coulombe-Huntington
,
Geneviève Boucher
,
Sébastien Lemieux
,
Mike Tyers
,
Josée Hébert
,
Guy Sauvageau
(2022).
Targeting PLZF Enhances Glucocorticoid Sensitivity in Acute Myeloid Leukemia
. Blood, 2022.
Guillaume Richard-Carpentier
,
Francois Beliveau
,
Sandrine Lacoste
,
Jean-Francois Spinella
,
Michael Vladovsky
,
Patrick Gendron
,
Sébastien Lemieux
,
Vincent-Philippe Lavallee
,
Guy Sauvageau
,
Josée Hébert
(2022).
IL1R1 Expression Predicts the Benefit from Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia and Intermediate-Risk Cytogenetics
. Blood, 2022.
Feghaly Albert
,
Gabrielle Thauvette
,
Marie-Christine Meunier
,
William Lemieux
,
Diane Fournier
,
Lucie Richard
,
Sébastien Lemieux
,
Guy Sauvageau
,
Sandra Cohen
,
David Desjardins
(2022).
ECT Match: Optimizing Small-Scale Cord Blood Banking through HLA Analysis
. Cord Blood Connect, 2022.
Zhaoguan Wu
,
Éric Bonneil
,
Michael Belford
,
Cornelia Boeser
,
Maria Virginia Ruiz Cuevas
,
Sébastien Lemieux
,
Jean-Jacques Dunyach
,
Pierre Thibault
(2022).
Proteogenomics and Differential Ion Mobility Enable the Exploration of the Mutational Landscape in Colon Cancer Cells
. Analytical Chemistry, 2022.
Michael Lang
,
Sébastien Lemieux
,
Josée Hébert
,
Guy Sauvageau
,
H Zawati Ma'n
(2021).
Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers, Clinicians, and Patients: Scoping Literature Review
. Journal of Medical Internet Research.
J. Krosl
,
M. E. Bordeleau
,
C. Moison
,
T. Macrae
,
I. Boivin
,
N. Mayotte
,
D. Gracias
,
I. Baccelli
,
V. P. Lavallee
,
R. Bisaillon
,
B. Lehnertz
,
R. Mendoza-Sanchez
,
R. Ruel
,
T. Bertomeu
,
J. Coulombe-Huntington
,
G. Boucher
,
N. Noronha
,
C. Pabst
,
M. Tyers
,
P. Gendron
,
S. Lemieux
,
F. Barabe
,
A. Marinier
,
J. Hebert
,
G. Sauvageau
(2021).
Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
. In: Blood Advances,
pp. bloodadvances.2021006047
,
https://doi.org/10.1182/bloodadvances.2021006047
.
M. Dumont-Lagace
,
Q. Li
,
M. Tanguay
,
J. Chagraoui
,
T. Kientega
,
G. B. Cardin
,
A. Brasey
,
A. Trofimov
,
C. Carli
,
I. Ahmad
,
N. M. Bambace
,
L. Bernard
,
T. L. Kiss
,
J. Roy
,
D. C. Roy
,
S. Lemieux
,
C. Perreault
,
F. Rodier
,
S. F. Dufresne
,
L. Busque
,
S. Lachance
,
G. Sauvageau
,
S. Cohen
,
J. S. Delisle
(2021).
UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections
. In: Transplant Cell Ther, (27), 1,
pp. 76.e1–76.e9
,
https://doi.org/10.1016/j.bbmt.2020.09.031
.
V. Janelle
,
M. Neault
,
M. E. Lebel
,
D. De Sousa
,
S. Boulet
,
L. Durrieu
,
C. Carli
,
C. Muzac
,
S. Lemieux
,
N. Labrecque
,
H. Melichar
,
F. Mallette
,
J. S. Delisle
(2021).
p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells
. In: Front. Immunol., (12),
pp. 698565
,
https://doi.org/10.3389/fimmu.2021.698565
,
https://www.frontiersin.org/articles/10.3389/fimmu.2021.698565/full
.
M. V. Ruiz Cuevas
,
M. P. Hardy
,
J. Holly
,
E Bonneil
,
C. Durette
,
M. Courcelles
,
J. Lanoix
,
C. Cote
,
L. M. Staudt
,
S. Lemieux
,
P. Thibault
,
C. Perreault
,
J. W. Yewdell
(2021).
Most non-canonical proteins uniquely populate the proteome or immunopeptidome
. In: Cell Rep, (34), 10,
pp. 108815
,
https://doi.org/10.1016/j.celrep.2021.108815
.
T. Daouda
,
M. Dumont-Lagace
,
A. Feghaly
,
Y. Benslimane
,
R. Panes
,
M. Courcelles
,
M. Benhammadi
,
L. Harrington
,
P. Thibault
,
F. Major
,
Y. Bengio
,
E. Gagnon
,
S. Lemieux
,
C. Perreault
(2021).
CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation
. In: PLoS computational biology, (17), 10,
pp. e1009482
,
https://doi.org/10.1371/journal.pcbi.1009482
.
Maria Virginia Ruiz
,
Anca Apavaloaei
,
Qingchuan Zhao
,
Marie-Pierre Hardy
,
Sébastien Lemieux
,
Claude Perreault
,
Grégory Ehx
(2021).
BamQuery: A new proteogenomic tool to explore the immunopeptidome and validate tumor‐specific antigens.
. European Journal of Immunology, 51 (S1), p. 60, 2021. doi: 10.1002/eji.202170200.
G. Ehx
,
J. D. Larouche
,
C. Durette
,
J. P. Laverdure
,
L. Hesnard
,
K. Vincent
,
M. P. Hardy
,
C. Theriault
,
C. Rulleau
,
J. Lanoix
,
E. Bonneil
,
A. Feghaly
,
A. Apavaloaei
,
N. Noronha
,
C. M. Laumont
,
J. S. Delisle
,
L. Vago
,
J. Hebert
,
G. Sauvageau
,
S. Lemieux
,
P. Thibault
,
C. Perreault
(2021).
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
. In: Immunity,
https://doi.org/10.1016/j.immuni.2021.03.001
.
J. D. Larouche
,
A. Trofimov
,
L. Hesnard
,
G. Ehx
,
Q. Zhao
,
K. Vincent
,
C. Durette
,
P. Gendron
,
J. P. Laverdure
,
E. Bonneil
,
C. Cote
,
S. Lemieux
,
P. Thibault
,
C. Perreault
(2020).
Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues
. In: Genome Med, (12), 1,
pp. 40
,
https://doi.org/10.1186/s13073-020-00740-7
,
https://www.ncbi.nlm.nih.gov/pubmed/32345368
.
C. V. De Jamblinne
,
B. Decelle
,
M. Dehghani
,
M. Joseph
,
N. Sriskandarajah
,
K. Leguay
,
B. Rambaud
,
S. Lemieux
,
P. P. Roux
,
D. R. Hipfner
,
S. Carreno
(2020).
STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity
. In: J Cell Biol, (219), 11,
https://doi.org/10.1083/jcb.201911035
.
Q. Zhao
,
J. P. Laverdure
,
J. Lanoix
,
C. Durette
,
C. Cote
,
E Bonneil
,
C. M. Laumont
,
P. Gendron
,
K. Vincent
,
M. Courcelles
,
S. Lemieux
,
D. G. Millar
,
P. S. Ohashi
,
P. Thibault
,
C. Perreault
(2020).
Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer
. In: Cancer Immunol Res, (8), 4,
pp. 544–555
,
https://doi.org/10.1158/2326-6066.Cir-19-0541
.
M. Courcelles
,
C. Durette
,
T. Daouda
,
J. P. Laverdure
,
K. Vincent
,
S. Lemieux
,
C. Perreault
,
P. Thibault
(2020).
MAPDP: A Cloud-Based Computational Platform for Immunopeptidomics Analyses
. In: J Proteome Res, (19), 4,
pp. 1873–1881
,
https://doi.org/10.1021/acs.jproteome.9b00859
.
L. Simon
,
J. F. Spinella
,
C. Y. Yao
,
V. P. Lavallee
,
I. Boivin
,
G. Boucher
,
E. Audemard
,
M. E. Bordeleau
,
S. Lemieux
,
J. Hebert
,
G. Sauvageau
(2020).
High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML
. In: Blood, (135), 21,
pp. 1882–1886
,
https://doi.org/10.1182/blood.2019003357
.
S. Cohen
,
J. Roy
,
S. Lachance
,
J. S. Delisle
,
A. Marinier
,
L. Busque
,
D. C. Roy
,
F. Barabe
,
I. Ahmad
,
N. Bambace
,
L. Bernard
,
T. Kiss
,
P. Bouchard
,
P. Caudrelier
,
S. Landais
,
F. Larochelle
,
J. Chagraoui
,
B. Lehnertz
,
S. Corneau
,
E. Tomellini
,
J. J. A. van Kampen
,
J. J. Cornelissen
,
M. Dumont-Lagace
,
M. Tanguay
,
Q. Li
,
S. Lemieux
,
P. W. Zandstra
,
G. Sauvageau
(2020).
Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study
. In: Lancet Haematol, (7), 2,
pp. e134–e145
,
https://doi.org/10.1016/s2352-3026(19)30202-9
.
R. Bisaillon
,
C. Moison
,
C. Thiollier
,
J. Krosl
,
M. E. Bordeleau
,
B. Lehnertz
,
V. P. Lavallee
,
T. Macrae
,
N. Mayotte
,
C. Labelle
,
G. Boucher
,
J. F. Spinella
,
I. Boivin
,
G. D'Angelo
,
S. Lavallee
,
A. Marinier
,
S. Lemieux
,
J. Hebert
,
G. Sauvageau
(2020).
Genetic characterization of ABT-199 sensitivity in human AML
. In: Leukemia, (34), 1,
pp. 63–74
,
https://doi.org/10.1038/s41375-019-0485-x
.
A. Trofimov
,
J. P. Cohen
,
Y. Bengio
,
C. Perreault
,
S. Lemieux
(2020).
Factorized embeddings learns rich and biologically meaningful embedding spaces using factorized tensor decomposition
. In: Bioinformatics, (36), Suppl_1,
pp. i417–i426
,
https://doi.org/10.1093/bioinformatics/btaa488
.
E. O. Audemard
,
P. Gendron
,
A. Feghaly
,
V. P. Lavallee
,
J. Hebert
,
G. Sauvageau
,
S. Lemieux
(2019).
Targeted variant detection using unaligned RNA-Seq reads
. In: Life Sci Alliance, (2), 4,
https://doi.org/10.26508/lsa.201900336
.
M. Dumont-Lagace
,
T. Daouda
,
L. Depoers
,
J. Zumer
,
Y. Benslimane
,
S. Brochu
,
L. Harrington
,
S. Lemieux
,
C. Perreault
(2019).
Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration
. In: Front Immunol, (10),
pp. 3118
,
https://doi.org/10.3389/fimmu.2019.03118
.
I. Baccelli
,
Y. Gareau
,
B. Lehnertz
,
S. Gingras
,
J. F. Spinella
,
S. Corneau
,
N. Mayotte
,
S. Girard
,
M. Frechette
,
V. Blouin-Chagnon
,
K. Leveille
,
I. Boivin
,
T. Macrae
,
J. Krosl
,
C. Thiollier
,
V. P. Lavallee
,
E. Kanshin
,
T. Bertomeu
,
J. Coulombe-Huntington
,
C. St-Denis
,
M. E. Bordeleau
,
G. Boucher
,
P. P. Roux
,
S. Lemieux
,
M. Tyers
,
P. Thibault
,
J. Hebert
,
A. Marinier
,
G. Sauvageau
(2019).
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
. In: Cancer Cell, (36), 1,
pp. 84–99.e8
,
https://doi.org/10.1016/j.ccell.2019.06.003
.
S. Garg
,
A. Reyes-Palomares
,
L. He
,
A. Bergeron
,
V. P. Lavallee
,
S. Lemieux
,
P. Gendron
,
C. Rohde
,
J. Xia
,
P. Jagdhane
,
C. Muller-Tidow
,
D. B. Lipka
,
S. Imren
,
R. K. Humphries
,
C. Waskow
,
B. Vick
,
I. Jeremias
,
G. Richard-Carpentier
,
J. Hebert
,
G. Sauvageau
,
J. B. Zaugg
,
F. Barabe
,
C. Pabst
(2019).
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML
. In: Blood, (134), 3,
pp. 263–276
,
https://doi.org/10.1182/blood.2018862383
.
C. Labelle
,
A. Marinier
,
S. Lemieux
(2019).
Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments
. In: Bioinformatics, (35), 14,
pp. i464–i473
,
https://doi.org/10.1093/bioinformatics/btz335
.
M. Marquis
,
C. Beaubois
,
V. P. Lavallee
,
M. Abrahamowicz
,
C. Danieli
,
S. Lemieux
,
I. Ahmad
,
A. Wei
,
S. B. Ting
,
S. Fleming
,
A. Schwarer
,
D. Grimwade
,
W. Grey
,
R. K. Hills
,
P. Vyas
,
N. Russell
,
G. Sauvageau
,
J. Hebert
(2019).
Correction: High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia
. In: Blood Cancer J, (9), 3,
pp. 28
,
https://doi.org/10.1038/s41408-019-0190-z
.
C. Moison
,
V. P. Lavallee
,
C. Thiollier
,
B. Lehnertz
,
I. Boivin
,
N. Mayotte
,
Y. Gareau
,
M. Frechette
,
V. Blouin-Chagnon
,
S. Corneau
,
S. Lavallee
,
S. Lemieux
,
A. Marinier
,
J. Hebert
,
G. Sauvageau
(2019).
Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition
. In: Blood Adv, (3), 4,
pp. 552–563
,
https://doi.org/10.1182/bloodadvances.2018028480
,
http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvances.2018028480
.
V. P. Lavallee
,
J. Chagraoui
,
T. Macrae
,
M. Marquis
,
A. Bonnefoy
,
J. Krosl
,
S. Lemieux
,
A. Marinier
,
C. Pabst
,
GE Rivard
,
J. Hebert
,
G. Sauvageau
(2018).
Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin
. In: Leukemia, (32), 6,
pp. 1349–1357
,
https://doi.org/10.1038/s41375-018-0069-1
.
C. M. Laumont
,
K. Vincent
,
L. Hesnard
,
E Audemard
,
E Bonneil
,
J. P. Laverdure
,
P. Gendron
,
M. Courcelles
,
M. P. Hardy
,
C. Cote
,
C. Durette
,
C. St-Pierre
,
M. Benhammadi
,
J. Lanoix
,
S. Vobecky
,
E. Haddad
,
S. Lemieux
,
P. Thibault
,
C. Perreault
(2018).
Noncoding regions are the main source of targetable tumor-specific antigens
. In: Sci Transl Med, (10), 470,
https://doi.org/10.1126/scitranslmed.aau5516
.
S. Lemieux
,
T. Sargeant
,
D. Laperriere
,
H. Ismail
,
G. Boucher
,
M. Rozendaal
,
V. P. Lavallee
,
D. Ashton-Beaucage
,
B. Wilhelm
,
J. Hebert
,
D. J. Hilton
,
S. Mader
,
G. Sauvageau
(2017).
MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets
. In: Nucleic Acids Res, (45), 13,
pp. e122
,
https://doi.org/10.1093/nar/gkx338
.
M. Dumont-Lagace
,
H. Gerbe
,
T. Daouda
,
J. P. Laverdure
,
S. Brochu
,
S. Lemieux
,
E Gagnon
,
C. Perreault
(2017).
Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus
. In: Front Immunol, (8),
pp. 1717
,
https://doi.org/10.3389/fimmu.2017.01717
.
L. Simon
,
V. P. Lavallee
,
M. E. Bordeleau
,
J. Krosl
,
I. Baccelli
,
G. Boucher
,
B. Lehnertz
,
J. Chagraoui
,
T. Macrae
,
R. Ruel
,
Y. Chantigny
,
S. Lemieux
,
A. Marinier
,
J. Hebert
,
G. Sauvageau
(2017).
Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
. In: Clin Cancer Res, (23), 22,
pp. 6969–6981
,
https://doi.org/10.1158/1078-0432.Ccr-17-1259
.
I. Baccelli
,
J. Krosl
,
G. Boucher
,
I. Boivin
,
V. P. Lavallee
,
J. Hebert
,
S. Lemieux
,
A. Marinier
,
G. Sauvageau
(2017).
A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens
. In: Blood Cancer J, (7), 2,
pp. e529
,
https://doi.org/10.1038/bcj.2017.10
.
A. Maiga
,
S. Lemieux
,
C. Pabst
,
V. P. Lavallee
,
M. Bouvier
,
G. Sauvageau
,
J. Hebert
(2016).
Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets
. In: Blood Cancer J, (6), 6,
pp. e431
,
https://doi.org/10.1038/bcj.2016.36
.
V. P. Lavallee
,
S. Lemieux
,
G. Boucher
,
P. Gendron
,
I. Boivin
,
R. N. Armstrong
,
G. Sauvageau
,
J. Hebert
(2016).
RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature
. In: Blood, (127), 20,
pp. 2498–501
,
https://doi.org/10.1182/blood-2016-03-703868
.
T. Daouda
,
C. Perreault
,
S. Lemieux
(2016).
pyGeno: A Python package for precision medicine and proteogenomics
. In: F1000Res, (5),
pp. 381
,
https://doi.org/10.12688/f1000research.8251.2
.
D. P. Granados
,
A. Rodenbrock
,
J. P. Laverdure
,
C. Cote
,
O. Caron-Lizotte
,
C. Carli
,
H. Pearson
,
V. Janelle
,
C. Durette
,
E. Bonneil
,
D. C. Roy
,
J. S. Delisle
,
S. Lemieux
,
P. Thibault
,
C. Perreault
(2016).
Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers
. In: Leukemia, (30), 6,
pp. 1344–54
,
https://doi.org/10.1038/leu.2016.22
.
H. Pearson
,
T. Daouda
,
D. P. Granados
,
C. Durette
,
E. Bonneil
,
M. Courcelles
,
A. Rodenbrock
,
J. P. Laverdure
,
C. Cote
,
S. Mader
,
S. Lemieux
,
P. Thibault
,
C. Perreault
(2016).
MHC class I-associated peptides derive from selective regions of the human genome
. In: J Clin Invest, (126), 12,
pp. 4690–4701
,
https://doi.org/10.1172/jci88590
.
V. P. Lavallee
,
S. Lemieux
,
G. Boucher
,
P. Gendron
,
I. Boivin
,
S. Girard
,
J. Hebert
,
G. Sauvageau
(2016).
Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations
. In: Leukemia, (30), 7,
pp. 1621–4
,
https://doi.org/10.1038/leu.2016.19
.
C. Pabst
,
A. Bergeron
,
V. P. Lavallee
,
J. Yeh
,
P. Gendron
,
G. L. Norddahl
,
J. Krosl
,
I. Boivin
,
E. Deneault
,
J. Simard
,
S. Imren
,
G. Boucher
,
K. Eppert
,
T. Herold
,
S. K. Bohlander
,
K. Humphries
,
S. Lemieux
,
J. Hebert
,
G. Sauvageau
,
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