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Occurrence and Detection of Phosphopeptide Isomers in Large-Scale Phosphoproteomics Experiments
The past decade has been marked by the emergence of selective affinity media and sensitive mass spectrometry instrumentation that …
Mathieu Courcelles
,
Gaëlle Bridon
,
Sébastien Lemieux
,
Pierre Thibault
Citation
DOI
ProteoConnections - a bioinformatics platform to facilitate proteome and phosphoproteome analyses
Novel and improved computational tools are required to transform large-scale proteomics data into valuable information of biological …
Mathieu Courcelles
,
Sébastien Lemieux
,
Laure Voisin
,
Sylvain Meloche
,
Pierre Thibault
Citation
DOI
The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation
Self/non-self discrimination is a fundamental requirement of life. Endogenous peptides presented by major histocompatibility complex …
Etienne Caron
,
Krystel Vincent
,
Marie-Hélène Fortier
,
Jean-Philippe Laverdure
,
Alexandre Bramoullé
,
Marie-Pierre Hardy
,
Grégory Voisin
,
P. Philippe Roux
,
Sébastien Lemieux
,
Pierre Thibault
,
Claude Perreault
Citation
DOI
A comprehensive map of the mTOR signaling network
The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and proliferation. mTOR signaling is frequently …
Etienne Caron
,
Samik Ghosh
,
Yukiko Matsuoka
,
Dariel Ashton-Beaucage
,
Marc Therrien
,
Sébastien Lemieux
,
Claude Perreault
,
P. Philippe Roux
,
Hiroaki Kitano
Citation
DOI
Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules
Proteasome-mediated proteolysis plays a crucial role in many basic cellular processes. In addition to constitutive proteasomes (CPs), …
Danielle Verteuil de
,
L. Tara Muratore-Schroeder
,
P. Diana Granados
,
Marie-Hélène Fortier
,
Marie-Pierre Hardy
,
Alexandre Bramoullé
,
Etienne Caron
,
Krystel Vincent
,
Sylvie Mader
,
Sébastien Lemieux
,
Pierre Thibault
,
Claude Perreault
Citation
DOI
Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans
Candida albicans is an important opportunistic human fungal pathogen that can cause both mucosal and systemic infections in …
Katharina Trunk
,
Patrick Gendron
,
André Nantel
,
Sébastien Lemieux
,
Terry Roemer
,
Martine Raymond
Citation
DOI
The phagosomal proteome in interferon-gamma-activated macrophages
The ability of macrophages to clear pathogens and elicit a sustained immune response is regulated by various cytokines, including …
Matthias Trost
,
Luc English
,
Sébastien Lemieux
,
Mathieu Courcelles
,
Michel Desjardins
,
Pierre Thibault
Citation
DOI
Genomewide location analysis of Candida albicans Upc2p a regulator of sterol metabolism and azole drug resistance
Upc2p, a transcription factor of the zinc cluster family, is an important regulator of sterol biosynthesis and azole drug resistance in …
Sadri Znaidi
,
Sandra Weber
,
Zin Osman Al-Abdin
,
Perrine Bomme
,
Saloua Saidane
,
Simon Drouin
,
Sébastien Lemieux
,
Xavier Deken De
,
François Robert
,
Martine Raymond
Citation
DOI
Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia
Proviral insertional mutagenesis is a powerful tool for the discovery of cancer-associated genes. The ability of integrated proviruses …
Martin Sauvageau
,
Michelle Miller
,
Sébastien Lemieux
,
Julie Lessard
,
Josée Hébert
,
Guy Sauvageau
Citation
DOI
Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme
Substrate recognition by the VS ribozyme involves a magnesium-dependent loop/loop interaction between the SLI substrate and the SLV …
Patricia Bouchard
,
Julie Lacroix-Labonté
,
Geneviève Desjardins
,
Philipe Lampron
,
Véronique Lisi
,
Sébastien Lemieux
,
François Major
,
Pascale Legault
Citation
DOI
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