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Correction of spatial bias in oligonucleotide array data
Background. Oligonucleotide microarrays allow for high-throughput gene expression profiling assays. The technology relies on the …
Philippe Serhal
,
Sébastien Lemieux
Citation
DOI
Funding considerations for the disclosure of genetic incidental findings in biobank research
The use of biobanks in biomedical research has grown considerably in recent years. As a result of the increasing analysis of tissue …
Leucegene Project
Citation
DOI
Genetic interaction between Kit and Scl
SCL/TAL1, a tissue-specific transcription factor of the basic helix-loop-helix family, and c-Kit, a tyrosine kinase receptor, control …
Lacombe Julie
,
Krosl Gorazd
,
Tremblay Mathieu
,
Gerby Bastien
,
Martin Richard
,
Lemieux Sebastien
,
Hoang Trang
Citation
DOI
Harnessing virtual machines to simplify next-generation DNA sequencing analysis
MOTIVATION - The growth of next-generation sequencing (NGS) has not only dramatically accelerated the pace of research in the field of …
Nocq Julie
,
Celton Magalie
,
Gendron Patrick
,
Lemieux Sebastien
Citation
DOI
Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions
The ERK1/2 MAP kinase pathway is an evolutionarily conserved signaling module that controls many fundamental physiological processes. …
Mathieu Courcelles
,
Christophe Frémin
,
Laure Voisin
,
Sébastien Lemieux
,
Sylvain Meloche
,
Pierre Thibault
Citation
DOI
RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells
Accurate quantification of gene expression by qRT-PCR relies on normalization against a consistently expressed control gene. However, …
Tara Macrae
,
Tobias Sargeant
,
Sébastien Lemieux
,
Josée Hébert
,
Eric Deneault
,
Guy Sauvageau
Citation
DOI
Transcriptome sequencing of neonatal thymic epithelial cells
In order to gain novel insights into thymus biology, we analysed the whole transcriptome of cortical and medullary thymic epithelial …
Charles St-Pierre
,
Sylvie Brochu
,
Ruiz Juan Vanegas
,
Maude Dumont-Lagacé
,
Sébastien Lemieux
,
Claude Perreault
Citation
DOI
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
In this study, we show the high frequency of spontaneous γδ T-cell leukemia (T-ALL) occurrence in mice with biallelic deletion of …
Camille Simon
,
Jalila Chagraoui
,
Jana Krosl
,
Patrick Gendron
,
Brian Wilhelm
,
Sébastien Lemieux
,
Geneviève Boucher
,
Pierre Chagnon
,
Simon Drouin
,
Raphaëlle Lambert
,
Claude Rondeau
,
Annie Bilodeau
,
Sylvie Lavallée
,
Martin Sauvageau
,
Josée Hébert
,
Guy Sauvageau
Citation
DOI
Helix-length compensation studies reveal the adaptability of the VS ribozyme architecture
Compensatory mutations in RNA are generally regarded as those that maintain base pairing, and their identification forms the basis of …
Julie Lacroix-Labonté
,
Nicolas Girard
,
Sébastien Lemieux
,
Pascale Legault
Citation
DOI
MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements
MHC I-associated peptides (MIPs) play an essential role in normal homeostasis and diverse pathologic conditions. MIPs derive mainly …
Paola Diana Granados
,
Wafaa Yahyaoui
,
M. Céline Laumont
,
Tariq Daouda
,
L. Tara Muratore-Schroeder
,
Caroline Côté
,
Jean-Philippe Laverdure
,
Sébastien Lemieux
,
Pierre Thibault
,
Claude Perreault
Citation
DOI
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