article-journal

Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly because of the lack of actionable immune targets. …
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CAMAP - Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation
MHC-I associated peptides (MAPs) play a central role in the elimination of virus-infected and neoplastic cells by CD8 T cells. However, …
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Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers Clinicians and Patients - Scoping Literature Review
Background - This study aims to identify a novel potential use for web portals in health care and health research - their adoption for …
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Most non-canonical proteins uniquely populate the proteome or immunopeptidome
Combining RNA sequencing, ribosome profiling, and mass spectrometry, we elucidate the contribution of non-canonical translation to the …
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Most non-canonical proteins uniquely populate the proteome or immunopeptidome
p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells
T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and …
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UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections
Rapid T cell reconstitution following hematopoietic stem cell transplantation (HSCT) is essential for protection against infections and …
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Factorized embeddings learns rich and biologically meaningful embedding spaces using factorized tensor decomposition
The recent development of sequencing technologies revolutionized our understanding of the inner workings of the cell as well as the way …
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Genetic characterization of ABT-199 sensitivity in human AML
Acute myeloid leukemias (AML) with mutations in the NPM1 gene (NPM1c+) represent a large AML subgroup with varying response to …
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Hematopoietic stem cell transplantation using single UM171-expanded cord blood - a single-arm phase 1–2 safety and feasibility study
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High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML
RUNX1 is mutated in ∼10% of adult acute myeloid leukemia (AML). Although most RUNX1 mutations in this disease are believed to be …
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