Récents

• Immunotherapeutic targeting of surfaceome heterogeneity in AML
• Transposable elements regulate thymus development and function
• BamQuery - a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens
• Mining Mass Spectra for Peptide Facts
• Pepid - a Highly Modifiable Bioinformatics-Oriented Peptide Search Engine
• Toward computing attributions for dimensionality reduction techniques
• Baseline Acute Myeloid Leukemia Prognosis Models using Transcriptomic and Clinical Profiles by Studying the Impacts of Dimensionality Reductions and Gene Signatures on Cox-Proportional Hazard
• Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers
• Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia
• Proteogenomics and Differential Ion Mobility Enable the Exploration of the Mutational Landscape in Colon Cancer Cells
• The tumor-specific antigen landscape of acute myeloid leukemia
• Two types of human TCR differentially regulate reactivity to self and non-self antigens
• Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
• Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
• CAMAP - Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation
• Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers Clinicians and Patients - Scoping Literature Review
• Most non-canonical proteins uniquely populate the proteome or immunopeptidome
• p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells
• UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections
• Factorized embeddings learns rich and biologically meaningful embedding spaces using factorized tensor decomposition
• Genetic characterization of ABT-199 sensitivity in human AML
• Hematopoietic stem cell transplantation using single UM171-expanded cord blood - a single-arm phase 1–2 safety and feasibility study
• High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML
• MAPDP - A Cloud-Based Computational Platform for Immunopeptidomics Analyses
• Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer
• Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration
• STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity
• Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues
• Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition
• Enhancing the drug discovery process - Bayesian inference for the analysis and comparison of dose–response experiments
• Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A NPM1 and FLT3-ITD triple-mutated AML
• Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
• Targeted variant detection using unaligned RNA-Seq reads
• The TCGA Meta-Dataset Clinical Benchmark
• High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia
• Holographic Neural Architectures
• Noncoding regions are the main source of targetable tumor-specific antigens
• Target variant detection in leukemia using unaligned RNA-Seq reads
• Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin
• Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
• Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus
• Warp - a method for neural network interpretability applied to gene expression profiles
• Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors
• Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers
• Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
• GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
• myCircos - Facilitating the Creation and Use of Circos Plots Online
• pyGeno - A Python package for precision medicine and proteogenomics
• RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature
• Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells
• EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations
• The NMR structure of the II–III–VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure
• The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
• A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila
• Identification of small molecules that support human leukemia stem cell activity ex vivo
• Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides
• SCL LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells
• Correction of spatial bias in oligonucleotide array data
• Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions
• RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells
• Transcriptome sequencing of neonatal thymic epithelial cells
• A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
• Helix-length compensation studies reveal the adaptability of the VS ribozyme architecture
• MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements
• Occurrence and Detection of Phosphopeptide Isomers in Large-Scale Phosphoproteomics Experiments
• ProteoConnections - a bioinformatics platform to facilitate proteome and phosphoproteome analyses
• The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation
• A comprehensive map of the mTOR signaling network
• Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules
• Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans
• The phagosomal proteome in interferon-gamma-activated macrophages
• Genomewide location analysis of Candida albicans Upc2p a regulator of sterol metabolism and azole drug resistance
• Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia
• Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme
• The MHC class I peptide repertoire is molded by the transcriptome
• Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1
• Automated extraction and classification of RNA tertiary structure cyclic motifs
• Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression
• RNA canonical and non-canonical base pairing types - a recognition method and complete repertoire