The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
Abstract
Guy Sauvageau, Josée Hébert and colleagues analyze exomes and transcriptomes in MLL-rearranged acute myeloid leukemias. They find frequent RAS pathway mutations, which sensitize leukemias to MEK and receptor tyrosine kinase inhibitors.,
Type
Publication
Nature Genetics
Sébastien Lemieux
Principal Investigator
Principal Investigator, Functional and Structural Bioinformatics Research Unit, IRIC | Scientific direction of the Bioinformatics platform | Associate Professor, Department of Biochemistry and Molecular Medicine, Université de Montréal