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Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme
Substrate recognition by the VS ribozyme involves a magnesium-dependent loop/loop interaction between the SLI substrate and the SLV …
Patricia Bouchard
,
Julie Lacroix-Labonté
,
Geneviève Desjardins
,
Philipe Lampron
,
Véronique Lisi
,
Sébastien Lemieux
,
François Major
,
Pascale Legault
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DOI
The MHC class I peptide repertoire is molded by the transcriptome
Under steady-state conditions, major histocompatibility complex (MHC) I molecules are associated with self-peptides that are …
Marie-Hélène Fortier
,
Etienne Caron
,
Marie-Pierre Hardy
,
Grégory Voisin
,
Sébastien Lemieux
,
Claude Perreault
,
Pierre Thibault
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DOI
Essential gene identification and drug target prioritization in Aspergillus fumigatus
Aspergillus fumigatus is the most prevalent airborne filamentous fungal pathogen in humans, causing severe and often fatal invasive …
Hu Wenqi
,
Sillaots Susan
,
Lemieux Sebastien
,
Davison John
,
Kauffman Sarah
,
Breton Anouk
,
Linteau Annie
,
Xin Chunlin
,
Bowman Joel
,
Becker Jeff
,
Jiang Bo
,
Roemer Terry
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DOI
Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1
In addition to their interactions with hetero-trimeric G proteins, seven-transmembrane domain receptors are now known to form …
Madeleine Héroux
,
Mireille Hogue
,
Sébastien Lemieux
,
Michel Bouvier
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DOI
Genome-Wide Fitness Test and Mechanism-of-Action Studies of Inhibitory Compounds in Candida albicans
Candida albicans is a prevalent fungal pathogen amongst the immunocompromised population, causing both superficial and life-threatening …
Xu Deming
,
Jiang Bo
,
Ketela Troy
,
Lemieux Sebastien
,
Veillette Karynn
,
Martel Nick
,
Davison John
,
Sillaots Susan
,
Trosok Steve
,
Bachewich Catherine
,
Bussey Howard
,
Youngman Phil
,
Roemer Terry
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DOI
Automated extraction and classification of RNA tertiary structure cyclic motifs
A minimum cycle basis of the tertiary structure of a large ribosomal subunit (LSU) X-ray crystal structure was analyzed. Most cycles …
Sébastien Lemieux
,
François Major
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DOI
Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression
Background
Sébastien Lemieux
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DOI
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery
Candida albicans is the primary fungal pathogen of humans. Despite the need for novel drugs to combat fungal infections [Sobel, J.D. …
Roemer Terry
,
Jiang Bo
,
Davison John
,
Ketela Troy
,
Veillette Karynn
,
Breton Anouk
,
Tandia Fatou
,
Linteau Annie
,
Sillaots Susan
,
Marta Catarina
,
Martel Nick
,
Veronneau Steeve
,
Lemieux Sebastien
,
Kauffman Sarah
,
Becker Jeff
,
Storms Reginald
,
Boone Charles
,
Bussey Howard
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DOI
RNA canonical and non-canonical base pairing types - a recognition method and complete repertoire
The problem of systematic and objective identification of canonical and non-canonical base pairs in RNA three-dimensional (3D) …
Sébastien Lemieux
,
François Major
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