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MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements
MHC I-associated peptides (MIPs) play an essential role in normal homeostasis and diverse pathologic conditions. MIPs derive mainly …
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Occurrence and Detection of Phosphopeptide Isomers in Large-Scale Phosphoproteomics Experiments
The past decade has been marked by the emergence of selective affinity media and sensitive mass spectrometry instrumentation that …
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ProteoConnections - a bioinformatics platform to facilitate proteome and phosphoproteome analyses
Novel and improved computational tools are required to transform large-scale proteomics data into valuable information of biological …
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The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation
Self/non-self discrimination is a fundamental requirement of life. Endogenous peptides presented by major histocompatibility complex …
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A comprehensive map of the mTOR signaling network
The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and proliferation. mTOR signaling is frequently …
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Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules
Proteasome-mediated proteolysis plays a crucial role in many basic cellular processes. In addition to constitutive proteasomes (CPs), …
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Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans
Candida albicans is an important opportunistic human fungal pathogen that can cause both mucosal and systemic infections in …
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The phagosomal proteome in interferon-gamma-activated macrophages
The ability of macrophages to clear pathogens and elicit a sustained immune response is regulated by various cytokines, including …
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Genomewide location analysis of Candida albicans Upc2p a regulator of sterol metabolism and azole drug resistance
Upc2p, a transcription factor of the zinc cluster family, is an important regulator of sterol biosynthesis and azole drug resistance in …
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Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia
Proviral insertional mutagenesis is a powerful tool for the discovery of cancer-associated genes. The ability of integrated proviruses …
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