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GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
Acute myeloid leukemia (AML) is a genetically heterogeneous hematologic malignancy, which is initiated and driven by a rare fraction of …
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pyGeno - A Python package for precision medicine and proteogenomics
pyGeno is a Python package mainly intended for precision medicine applications that revolve around genomics and proteomics. It …
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RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature
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Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells
Establishment of self-tolerance in the thymus depends on promiscuous expression of tissue-restricted Ags (TRA) by thymic epithelial …
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EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations
The genetic and transcriptional signature of EVI1 (ecotropic viral integration site 1)-rearranged (EVI1-r) acute myeloid leukemias …
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The NMR structure of the II–III–VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure
As part of an effort to structurally characterize the complete Neurospora VS ribozyme, NMR solution structures of several subdomains …
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The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
Guy Sauvageau, Josée Hébert and colleagues analyze exomes and transcriptomes in MLL-rearranged acute myeloid leukemias. They find …
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A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila
The small GTPase RAS is among the most prevalent oncogenes. The evolutionarily conserved RAF-MEK-MAPK module that lies downstream of …
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Identification of small molecules that support human leukemia stem cell activity ex vivo
Leukemic stem cells (LSCs) are considered a major cause of relapse in acute myeloid leukemia (AML). Defining pathways that control LSC …
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Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides
For decades, the global impact of genomic polymorphisms on the repertoire of peptides presented by major histocompatibility complex …
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