article-journal

Targeted variant detection using unaligned RNA-Seq reads
Mutations identified in acute myeloid leukemia patients are useful for prognosis and for selecting targeted therapies. Detection of …
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High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia
Abstract
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Noncoding regions are the main source of targetable tumor-specific antigens
Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but few have been identified thus far. We therefore …
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Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin
Acute promyelocytic leukemia (APL) is a medical emergency because of associated lethal early bleeding, a condition preventable by …
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Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
Purpose -RUNX1-mutated (RUNX1mut) acute myeloid leukemia (AML) is associated with adverse outcome, highlighting the urgent need for a …
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Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus
Thymic aging precedes that of other organs and is initiated by the gradual loss of thymic epithelial cells (TECs). Based on in vitro …
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MiSTIC an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets
Genome-wide transcriptome profiling has enabled non-supervised classification of tumours, revealing different sub-groups characterized …
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Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors
In this study, we analyzed RNA-sequencing data of 14 samples characterized by biallelic CEBPA (CEBPA(bi)) mutations included in the …
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Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers
Based on transcriptomic analyses of thousands of samples from The Cancer Genome Atlas, we report that expression of constitutive …
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Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
In view of recent reports documenting pervasive translation outside of canonical protein-coding sequences, we wished to determine the …
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