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High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML
RUNX1 is mutated in ∼10% of adult acute myeloid leukemia (AML). Although most RUNX1 mutations in this disease are believed to be …
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MAPDP - A Cloud-Based Computational Platform for Immunopeptidomics Analyses
The immunopeptidome corresponds to the repertoire of peptides presented at the cell surface by the major histocompatibility complex …
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Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer
High-grade serous ovarian cancer (HGSC), the principal cause of death from gynecologic malignancies in the world, has not significantly …
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Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration
During gestation, sex hormones cause a significant thymic involution which enhances fertility. This thymic involution is rapidly …
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STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity
Proteins of the ezrin, radixin, and moesin (ERM) family control cell and tissue morphogenesis. We previously reported that moesin, the …
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Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues
Endogenous retroelements (EREs) constitute about 42% of the human genome and have been implicated in common human diseases such as …
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Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition
Patients diagnosed with acute myeloid leukemia with complex karyotype (CK AML) have an adverse prognosis using current therapies, …
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Enhancing the drug discovery process - Bayesian inference for the analysis and comparison of dose–response experiments
The efficacy of a chemical compound is often tested through dose–response experiments from which efficacy metrics, such as the IC50, …
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Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A NPM1 and FLT3-ITD triple-mutated AML
FLT3, DNMT3A, and NPM1 are the most frequently mutated genes in cytogenetically normal acute myeloid leukemia (AML), but little is …
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Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
To identify therapeutic targets in acute myeloid leukemia (AML), we chemically interrogated 200 sequenced primary specimens. …
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