Guy Sauvageau

Latest

• Baseline Acute Myeloid Leukemia Prognosis Models using Transcriptomic and Clinical Profiles by Studying the Impacts of Dimensionality Reductions and Gene Signatures on Cox-Proportional Hazard
• Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
• Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
• Legal and Ethical Considerations for the Design and Use of Web Portals for Researchers Clinicians and Patients - Scoping Literature Review
• UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections
• Genetic characterization of ABT-199 sensitivity in human AML
• Hematopoietic stem cell transplantation using single UM171-expanded cord blood - a single-arm phase 1–2 safety and feasibility study
• High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML
• Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition
• Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A NPM1 and FLT3-ITD triple-mutated AML
• Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
• Targeted variant detection using unaligned RNA-Seq reads
• High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia
• Target variant detection in leukemia using unaligned RNA-Seq reads
• Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin
• Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
• Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors
• Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers
• GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
• RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature
• EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations
• The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
• Identification of small molecules that support human leukemia stem cell activity ex vivo
• SCL LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells
• RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells
• A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
• Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia